EDUCATION
Bachelor 1995.09 – 1998.07, Yantai University, Biochemistry
Ph.D 1998.09 – 2004.01, Fudan University, Genetics
WORK EXPERIENCE
2004.01–2004.12: Research fellow, Chinese National Human Genome Center at Shanghai, China
2005.01–2005.09: Postdoctoral Research Fellow, Harvard Medical School, USA
2005.10–2009.05: Postdoctoral Research Fellow, Stanford University School of Medicine, USA
2009.05–Now: Professor, Shandong University School of Life Sciences, China
RESEARCH INTERST
1. Molecular mechanism of stereocilia development and maintenance.
2. Molecular mechanism of hearing transduction.
3. Molecular mechanism of hearing loss.
SELECTED PUBLICATIONS (“*” indicates corresponding author.)
1. Wang X, Liu S, Cheng Q, Qu C, Ren R, Du H, Li N, Yan K, Wang Y, Xiong W*, Xu Z*. CIB2 and CIB3 regulate stereocilia maintenance and mechanoelectrical transduction in mouse vestibular hair cells. J Neurosci. 2023;43(18):3219-3231. (Featured article)
2. Guan Y, Du HB, Yang Z, Wang YZ, Ren R, Liu WW, Zhang C, Zhang JH, An WT, Li NN, Zeng XX, Li J, Sun YX, Wang YF, Yang F, Yang J, Xiong W, Yu X, Chai RJ, Tu XM*, Sun JP*, Xu ZG*. Deafness-associated ADGRV1 mutation impairs USH2A stability through improper phosphorylation of WHRN and WDSUB1 recruitment. Adv Sci (Weinh). 2023;10(16):e2205993.
3. Wang H, Du H, Ren R, Du T, Lin L, Feng Z, Zhao D, Wei X, Zhai X, Wang H, Dong T, Sun JP, Wu H, Xu Z*, Lu Q*. Temporal and spatial assembly of inner ear hair cell ankle link condensate through phase separation. Nat Commun. 2023;14(1):1657.
4. Ren R, Xing H, Wang X, Du H, Wang Y, Xu Z*. Loss of TMCC2 activates endoplasm reticulum stress and causes auditory hair cell death. Hum Mol Genet. 2023;32(10):1622-1633. (Cover story)
5. Wang Y, Zhang C, Peng W, Du H, Xi Y, Xu Z*. RBM24 is required for mouse hair cell development through regulating pre-mRNA alternative splicing and mRNA stability. J Cell Physiol. 2023;238(5):1095-1110.
6. Zhai X, Du H, Shen Y, Zhang X, Chen Z, Wang Y, Xu Z*. FCHSD2 is required for stereocilia maintenance in mouse cochlear hair cells. J Cell Sci. 2022;135(16):jcs259912.
7. Yan K, Zong W, Du H, Zhai X, Ren R, Liu S, Xiong W, Wang Y, Xu Z*. BAIAP2L2 is required for the maintenance of mechanotransducing stereocilia of cochlear hair cells. J Cell Physiol. 2022;237:774-788.
8. Du H, Zou L, Ren R, Li N, Li J, Wang Y, Sun J, Yang J, Xiong W*, Xu Z*. Lack of PDZD7 long isoform disrupts ankle-link complex and causes hearing loss in mice. FASEB J., 2020;34:1136-1149.
9. Wang Y, Li J, Yao X, Li W, Du H, Tang M, Xiong W, Chai R*, Xu Z*. Loss of CIB2 causes profound hearing loss and abolishes mechanoelectrical transduction in mice. Front. Mol. Neurosci., 2017;10:401.
10. Cheng X, Shao M, Li J, Wang Y, Qi J, Xu Z*, Shi D*. Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish. Nat. Commun. 2017;8:1353.
BOOKS
1. Xu Z, Peng AW, Xiong W. Hair bundles - Development, maintenance, and function. 2021, Lausanne: Frontiers Media SA. ISBN 978-2-88971-968-6.
2. Xiong W, Xu Z. Mechanotransduction of the hair cell. 2018, Springer. ISBN: 9789811085574 (online) 9789811085567 (print).
