EDUCATION
Ph. D., 1995.9-1998.6 Nanjing Normal University
M. Sc., 1982.2-1984.12, Shandong University
B. Sc., 1978.2-1981.1, Shandong Normal University
WORK EXPERIENCE
1997.9-present, Professor, Shandong University
1992.9-1997.7, Associate Professor, Shandong University
1987.9-1992.7, Lecturer, Shandong University
1984.12-1987.7, Assistant Professor, Shandong University
RESEARCH INTERESTS
We are interested in invertebrate innate immunity, especially in crustacean immunity. Our research work includes pattern recognition, signal pathways and effectors in immune responses of crustacean. The purpose of our study is to understand the interaction mechanisms of host and pathogens in crustacean innate immunity and finding the methods for disease control in crustacean aquaculture.
RESEARCH PROJECTS:
1. 2017.1-2021.12 Microbiotas and their homeostatic regulation in shrimp, A Key Project of National Natural Science Foundation of China.
2. 2015.1—2018.12 Functions of Scavenger Receptors in Shrimp Defense Responses. A General Project of National Natural Science Foundation of China.
3. 2012.1—2016.Function and Mechanisms of Genes against White Spot Syndrome Virus in Shrimp. A Key Project of National Natural Science Foundation of China.
4. 2012.1-2016.12 The Mechanism of immunization therapy and Critical Technology for control of White Spot Syndrome Virus. National Basic Research Program of China (973 Program).
SELECTED PUBLICATIONS (*corresponding author)
1. GJ Niu, S Wang, JD Xu, MC Yang, JJ Sun, ZH He, XF Zhao, JX Wang*. The polymeric immunoglobulin receptor-like protein from Marsupenaeus japonicus is a receptor for white spot syndrome virus infection. PLoS Pathog. 2019 Feb 6;15(2):e1007558. doi: 10.1371/journal.ppat.1007558.
2. GJ Niu, JD Xu, WJ Yuan, JJ Sun, MC Yang, ZH He, XF Zhao and JX Wang*. Protein Inhibitor of Activated STAT (PIAS) Negatively Regulates the JAK/STAT Pathway by Inhibiting STAT Phosphorylation and Translocation. Front. Immunol. 2018 Oct 26,9:2392. doi: 10.3389/fimmu.2018.02392
3. JD Xu, MQ Diao, GJ Niu, XW Wang, XF Zhao, JX Wang*. A Small GTPase, RhoA, Inhibits Bacterial Infection Through Integrin Mediated Phagocytosis in Invertebrates.Front Immunol. 2018 Aug 30; 9:1928. doi: 10.3389/fimmu.2018.01928
4. JJ Sun, S Xu, ZH He, XZ Shi, XF Zhao, JX Wang*. Activation of Toll Pathway Is Different between Kuruma Shrimp and Drosophila. Front Immunol. 2017 Sep 20; 8:1151.
5. JJ Sun1, JF Lan1, XF Zhao, Vasta GR, JX Wang*. Binding of a C-type lectin's coiled-coil domain to the Domeless receptor directly activates the JAK/STAT pathway in the shrimp immune response to bacterial infection. PLoS Pathog. 2017 Sep 20; 13(9):e1006626.
6. XW Wang*, J Gao, YH Xu, JD Xu, ZX Fan, XF Zhao, JX Wang*. Novel Pattern Recognition Receptor Protects Shrimp by Preventing Bacterial Colonization and Promoting Phagocytosis. J. Immunol. 2017 Apr 15; 198(8):3045-3057
7. JD Xu, HS Jiang, TD Wei, KY Zhang, XW Wang, XF Zhao, JX Wang*. Interaction of the Small GTPase Cdc42 with Arginine Kinase Restricts White Spot Syndrome Virus in Shrimp. J. Virol. 2017 March; 91(5):e01916-16. This article was chosen by editors as a spotlight article: http://jvi.asm.org/content/91/5/e00017-17.full
8. MC Yang, XZ Shi, HT Yang, JJ Sun, L Xu, XW Wang, XF Zhao, JX Wang*. Scavenger Receptor C Mediates Phagocytosis of White Spot Syndrome Virus and Restricts Virus Proliferation in Shrimp. PLoS Pathog. 2016 Dec 27; 12(12):e1006127.
9. JJ Sun, JF Lan, XZ Shi, MC Yang, GJ Niu, D Ding, XF Zhao, XQ Yu, JX Wang*.β-Arrestins Negatively Regulate the Toll Pathway in Shrimp by Preventing Dorsal Translocation and Inhibiting Dorsal Transcriptional Activity. J. Biol. Chem. 2016 Apr 1; 291(14):7488-504.
10. XW Wang, YH Xu, JD Xu, XF Zhao, JX Wang*.Collaboration between a soluble C-type lectin and calreticulin facilitates white spot syndrome virus infection in shrimp. J. Immunol. 2014 Sep 1; 193(5):2106-17.
11. XW Wang, JD Xu, XF Zhao, Vasta GR, JX Wang*. A shrimp C-type lectin inhibits proliferation of the hemolymph microbiota by maintaining the expression of antimicrobial peptides. J. Biol. Chem. 2014 Apr 25; 289(17):11779-90.
12. XW Wang, XF Zhao, JX Wang*. C-type lectin binds to β-integrin to promote hemocytic phagocytosis in an invertebrate. J. Biol. Chem. 2014 Jan 24; 289(4):2405- 2414.
13. JF Lan, XC Li, JJ Sun, J Gong, XW Wang, XZ Shi, LJ Shi, YD Weng XF Zhao, JX Wang* Prohibitin interacts with envelope proteins of white spot syndrome virus and prevents infection in red swamp crayfish Procambarus clarkii. J. Virol. 2013 Dec; 87(23):12756-65.
14. AJ Chen, L Gao, XW Wang, XF Zhao, JX Wang*. SUMO conjugating enzyme E2 UBC9 mediates viral immediate-early protein SUMOylation in crayfish to facilitate reproduction of white spot syndrome virus. J. Virol. 2013 Jan; 87(1):636-47.
15. AJ Chen S Wang XF Zhao, XQ Yu, JX Wang*. E2 Enzyme from Chinese White Shrimp Inhibits Replication of White Spot Syndrome Virus and Ubiquitinates its RING Domain Proteins. J. Virol. 2011 Aug; 85(16):8069-79.
16. S Wang , N Liu, AJ Chen, XF Zhao, JX Wang*. TRBP Homologue Interacts with Eukaryotic Initiation Factor 6 (eIF6) in Fenneropenaeus chinensis. J. Immunol. 2009 May 1; 182(9):5250-5258.
AWARDS
1. The mechanisms of innate immune defenses against bacteria and viruses, Ministry of Education Award for the achievements of scientific research in Colleges and universities-Natural Science Award (First class).
