EDUCATION
Ph.D, 2003-2006 Shandong University Cell biology
Master, 2000-2003 Shandong agriculture university veterinary immunology
Bachelor, 1996-2000 Shandong agriculture university animal husbandry
WORK EXPERIENCE
2006.7-2008.9 Shandong University lecturer
2008.9-2017.8 Shandong University associate professor
2017.9 -now Shandong University professor
2011.7-2012.8 East Tennessee state university visiting scholar
RESEARCH INTERESTS
1.Vascular endothelial cell autophagy and transdifferentiation
2. Angiogenesis
3.Cardiomyocyte apoptosis, autophagy and differentiation
RESEARCH PROGRAMS
1. 2017.1—2020.12. Study on the molecular mechanisms of cardiomyocyte mitophagy promoted by sphingosylphosphorylcholine. National Natural Science Foundation（31671180）
2. 2014.1—2017.12. Research on the function of MiR-155/β-arrestin 2/GSK3βpathway in differentiation of resident Sca-1+ cardiac stem cell to cardiomyocyte. National Natural Science Foundation（31371158）
3. 2010.12—2013.12. Study on the mechanisms of sphingosylphosphorylcholine induced autophagy of vascular endothelial cells. National Natural Science Foundation（31070999）
4. 2010.12—2013.12. Research on the angiogenesis mechanisms based on the chemical small moleculars. China Postdoctoral Science Foundation Funded Project（201003638）
5. 2010.1-2013.1. Application of chemical small moleculars in differentiation, senescence and apoptosis of bone marrow stromal cells. Independentinnovation foundation of Shandong University (2009JC007)
SELECTED PUBLICATIONS
1.D Ge, J Gao, L Han, Y Li, H LiuHH Liu, WC Yang, F Chang, J Liu, M Yu, J Zhao*. Novel effects of sphingosylphosphorylcholine on the apoptosis of breast cancer via autophagy/AKT/p38 and JNK signaling. J Cell Physiol. 2019 Jul;234(7):11451-11462.
2.D Ge, H YueHW Yue, H LiuHH Liu, J Zhao*. Emerging roles of sphingosylphosphorylcholine in modulating cardiovascular functions and diseases. Acta Pharmacol Sin. 2018 Dec;39(12):1830-1836.
3.H Liu, P Liu, X Shi, D Yin, J Zhao*. NR4A2 protects cardiomyocytes against myocardial infarction injury by promoting autophagy. Cell Death Discov. 2018 Feb 15;4:27.
4.PP Li, H LiuHH Liu, SH Sun, XX Shi, WC Yang, GH Su, J Zhao*. Aspirin alleviates cardiac fibrosis in mice by inhibiting autophagy. Acta Pharmacol Sin. 2017 Apr;38(4):488-497.
4.XX Shi, WJLi, HH Liu, Deling Yin and JZhao. The ROS/NF-κB/NR4A2 pathway is involved in H2O2 induced apoptosis of resident cardiac stem cells via autophagy
Oncotarget, 2017; 8:77634-77648.
5. J Liu, H Fu, F Chang, J Wang, S Zhang, Caudle Y, J Zhao*, D Yin*. Sodium orthovanadate suppresses palmitate-induced cardiomyocyte apoptosis by regulation of the JAK2/STAT3 signaling pathway. Apoptosis. 2016 May;21(5):546-57.
6.F Chang, J Liu, H Fu, J Wang, F Li, H Yue, W Li, J Zhao*, D Yin*. GSK-3β promotes PA-induced apoptosis through changing β-arrestin 2 nucleus location in H9c2 cardiomyocytes. Apoptosis. 2016 Sep;21(9):1045-55.
7.J Liu, H Fu, F Chang, J Wang, S Zhang, Caudle Y, J Zhao*, D Yin*. Sodium orthovanadate suppresses palmitate-induced cardiomyocyte apoptosis by regulation of the JAK2/STAT3 signaling pathway. Apoptosis. 2016 Sep;21(9):1045-55.
8.Wenjing Li, Honghong Liu, Pingping Liu, Deling Yin, Shangli Zhang, Jing Zhao*. Sphingosylphosphorylcholine promotes the differentiation of resident Sca-1 positive cardiac stem cells to cardiomyocytes through lipid raft/JNK/STAT3 and β-catenin signaling pathways. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2016,1579-1588.
9.H YueHW Yue, J Liu, PP Liu, WJ Li, F Chang, JY Miao, J Zhao*. Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy. Biochim Biophys Acta. 2015 Sep;1851(9):1186-93.
10.D Ge, Q Jing, W Zhao, H Yue, L Su, S Zhang, J Zhao*. Finding ATF4/p75NTR/IL-8 signal pathway in endothelial-mesenchymal transition by safrole oxide. PLoS One. 2014 Apr 7;9(4):e92661.
