EDUCATION
2000-2005 Post Doctorl Diabetes Center, Dept. of Medicine Albert Einstein College of Medicine (AECOM)
1995-2000 Ph.D. Dept. of Molecular and Cellular Biology, Roswell Park Cancer Institute (RPCI), SUNY at Buffalo
1989-1993 B.S. Dept. of Biology, Shandong University
WORK EXPERIENCES
2005-present: Professor, School of Life Sciences, Shandong University
2002-2005 Research Associate, AECOM, NYC, NY, US
2000-2002 Research Fellow, AECOM, NYC, NY, US
1995-2000 Research Affiliate, RPCI, SUNY at Buffalo, Buffalo, NY, US
1993-1995 Assistant Engineer, Shanhai Biotech. Ltd., Jiann, Shandong, P.R.China
RESEARCH INTEREST
One of my interests is in the mouse models, pearl and pale ear, for HERMANSKY-PUDLAK SYNDROME (HPS). Besides of classical phenotypes, these mouse mutants bear reduced fertility in both male and females. The female pearl mouse may serve as a model for infantile uterus which is one of the major reasons for female infertility.
Another interest of my research is the sex maturation and gamete formation. With the advanced CAS9 technology, we already mutated several genes in zebrafish which will be great models for us to study the detailed regulation mechanisms and provide new insights for human infertility.
TEACHING DUTIES
1. Cell Biology and Cell Biology Lab for sophomore students
2. Methodology in Life Sciences Research for junior students
3. Seminar for graduate students
GRADUATED FROM MY LAB
Since 2009, 8 Ph.D. and 18 Master students have graduated from my lab and I am proud of them.
SELECTED PUBLICATIONS
1. L Chen, J Yan, J Shi, W Sun, Z Chen, J Yu, J Qi, Y Du, H Zhang, L Feng*. Zebrafish intelectin 1 (zITLN1) plays a role in the innate immune response. L ChenJ YanJ ShiW SunZ ChenJ YuJ QiY DuH ZhangL FengFish Shellfish Immunol. 2018 Dec;83:96-103. doi: 10.1016/j.fsi.2018.09.004. Epub 2018 Sep 6.
2. J Yan, L Chen, Z Liu, Y Chen, Y Sun, J Han, L Feng. The D5 region of the intelectin domain is a new type of carbohydrate recognition domain in the intelectin gene family.. Dev Comp Immunol. 2018 Aug;85:150-160. doi: 10.1016/j.dci.2018.02.021. Epub 2018 Apr
3. L Chen, J Yan, W Sun, Y Zhang, C Sui, J Qi, Y Du, L Feng. A zebrafish intelectin ortholog agglutinates both Gram-negative and Gram-positive bacteria with binding capacity to bacterial polysaccharide. L ChenJ YanW SunY ZhangC SuiJ QiY DuL FengFish Shellfish Immunol. 2016 Aug;55:729-36. doi: 10.1016/j.fsi.2016.06.023. Epub 2016 Jun 18.
4. R Jing*, X Dong, K Li, J Yan, X Chen, L Feng*. The Ap3b1 gene regulates the ocular melanosome biogenesis and tyrosinase distribution differently from the Hps1 gene.R JingX DongK LiJ YanX ChenL Feng Exp Eye Res. 2014 Nov;128:57-66. doi: 10.1016/j.exer.2014.08.010. Epub 2014 Aug 24.
5. R Jing, X Dong, K Li, J Zhang, J Yan, L Feng*. Two distinct phenotypes in pigmented cells of different embryonic origins in eyes of pale ear mice.R JingX DongK LiJ ZhangJ YanL Feng Exp Eye Res. 2014 Feb;119:35-43. doi: 10.1016/j.exer.2013.12.007. Epub 2013 Dec 17
6. J Yan*, L Xu, Y Zhang, C Zhang, C Zhang, F Zhao, L Feng*. Comparative genomic and phylogenetic analyses of the intelectin gene family: implications for their origin and evolution. J YanL XuY ZhangC ZhangC ZhangF ZhaoL FengDev Comp Immunol. 2013 Oct;41(2):189-99. doi: 10.1016/j.dci.2013.04.016. Epub 2013 Apr 30.
7. J Yan, X Dong, Y Kong, Y Zhang, R Jing, L Feng*. Identification and primary immune characteristics of an amphioxus akirin homolog. J YanX DongY KongY ZhangR JingL FengFish Shellfish Immunol. 2013 Aug;35(2):564-71. doi: 10.1016/j.fsi.2013.05.020. Epub 2013 May 31.
8. J Yan, C Zhang, Y Zhang, K Li, L Xu, L Guo, Y Kong, L Feng*. Characterization and comparative analyses of two amphioxus intelectins involved in the innate immune response. J YanC ZhangY ZhangK LiL XuL GuoL GuoY KongL FengFish Shellfish Immunol. 2013 May;34(5):1139-46. doi: 10.1016/j.fsi.2013.01.017. Epub 2013 Feb 18.
9. J Yan, J Wang, Y Zhao, J Zhang, C Bai, C Zhang, C Zhang, K Li, H Zhang, X Du, L Feng*. Identification of an amphioxus intelectin homolog that preferably agglutinates gram-positive over gram-negative bacteria likely due to different binding capacity to LPS and PGN. J YanJ WangY ZhaoJ ZhangC BaiC ZhangC ZhangK LiH ZhangX DuL FengFish Shellfish Immunol. 2012 Jul;33(1):11-20. doi: 10.1016/j.fsi.2012.03.023. Epub 2012 Mar 24.
10. Y Zhang, H Zhang, Y Kong, L Feng*. Identification and characterization of an amphioxus matrix metalloproteinase homolog BbMMPL2 responding to bacteria challenge. Y ZhangH ZhangY KongL FengDev Comp Immunol. 2012 Jul;37(3-4):371-80. doi: 10.1016/j.dci.2012.02.015. Epub 2012 Mar 19.
11. XM Du, Y Yan, ZL Bai*, JP Zhang, Z Wang, LL Liu, LJ Feng*. Evaluation of the cytotoxicity of a two photon absorbing fluorescence compound on human HepG2 cells and its application to tracking human hepatic cancer cells in mice.X DuY YanZL BaiJ ZhangZ WangLL LiuL Feng Biotech Histochem. 2010 Apr;85(2):107-13. doi:10.1080/10520290903149588
12. B Li, Y Lin, W Zhang, M Shao, Y Bian, S Huang, L Feng*, H Zhang*. Phylogenetic analysis and expression pattern of the AmphiCaBP-like gene from amphioxus, encoding a novel member of the calmodulin-like subfamilyB LiY LinW ZhangM ShaoY BiaoS HuangL FengH Zhang DNA Seq. 2007 Jun;18(3):228-34.
PAST PUBLICATIONS IN 2006.11
1.LJ Feng,Arvan P . The trafficking of alpha(1)-antitrypsin, a post-Golgi secretory pathway marker, in INS-1 pancreatic beta cells. JOURNAL OF BIOLOGICAL CHEMISTRY 278 (34): 31486-31494 AUG 22 2003SCI IF: 6.482 Times Cited: 92. Arvan P, BY Zhang, LJ Feng, et al. Lumenal protein multimerization in the distal secretory pathway/secretory granules. CURRENT OPINION IN CELL BIOLOGY 14 (4): 448-453 AUG 2002. SCI IF: 19.022 Times Cited: 19
3. LJ Feng, Novak EK, Hartnell LM, et al. The Hermansky-Pudlak syndrome 1 (HPS1) and HPS2 genes independently contribute to the production and function of platelet dense granules, melanosomes, and lysosomes.BLOOD 99 (5): 1651-1658 MAR 1 2002.
SCI IF: 9.273 Times Cited: 27
4. Swank RT, Novak EK, LJ Feng, et al. Abnormal vesicular trafficking in mouse models of Hermansky-Pudlak syndrome. PIGMENT CELL RESEARCH 13: 59-67 Suppl. 8 2000.
SCI IF: 3.0 Times Cited: 39
5. LJ Feng, Rigatti BW, Novak EK, et al. Genomic structure of the mouse Ap3b1 gene in normal and pearl mice.GENOMICS 69 (3): 370-379 NOV 1 2000.SCI IF: 3.425 Times Cited: 76
6. LJ Feng, LJ Zhang, S Jiang, et al. Abnormal expression and subcellular distribution of subunit proteins of the AP-3 adaptor complex lead to platelet storage pool deficiency in the pearl mouse.BLOOD 94 (1): 146-155 JUL 1 1999.SCI IF: 8.372 Times Cited: 39
7.LJ Feng, Seymour AB, S Jiang, et al. The beta 3A subunit gene (Ap3b1) of the AP-3 adaptor complex is altered in the mouse hypopigmentation mutant pearl, a model for Hermansky-Pudlak syndrome and night blindness.HUMAN MOLECULAR GENETICS 8 (2): 323-330 FEB 1999.SCI IF: 9.307 Times Cited: 126
8. Swank RT, Novak EK, LJ Feng, et al. Mouse models of Hermansky Pudlak Syndrome: A review.PIGMENT CELL RESEARCH 11 (2): 60-80 APR 1998.SCI IF: 3.0 Times Cited: 1218Genome Conference. 1997.
