EDUCATION
1992-1998, Ph.D.,Nagoya University, Nagoya, Japan
1983-1986, M.Sc., Biological Engineering Centre, Wuhan University
1979-1983, B.SC., Department of Biology, Wuhan University
WORK EXPERIENCE
1998-Present, Professor of Cell Biology, Shandong University
1986-1992, Lectuer, Department of Biology, Shandong University
RESEARCH INTERESTS
1.Long noncoding RNAs in Autophagy and Apoptosis regulation of Vascular Endothelial Cells
2.Differentiation of Mesenchymal Stem Cells and embryonic stem cells
3.Application of Chemical Small Molecules in the Mechanism Research of Cardiovascular Diseases
RESEARCH PROGRAMS
1.Studying on the mechanism of a new long noncoding RNA suppressing vascular endothelial cell apoptosis.
The National Natural Science Foundation of China. (Grant No. 91539105).
2.Study on the mechanisms by which integrin beta4 enters cellular nucleus and promotes apoptosis.
The National Natural Science Foundation of China. (Grant No. 31570834).
3.Identification of proteins interacting with annexin A7 and the mechanism by which they regulate autophagy of vascular endothelial cells.
The National Natural Science Foundation of China. (Grant No. 31270877).
SELECTED PUBLICATIONS
1.S Huang, Lu , D Ge, N Meng, Y Li, L Su, S Zhang, B Zhao*, J Miao * . A new microRNA signal pathway regulated by long noncoding RNA FLJ11812 in autophagy and inflammation of vascular endothelial cells. Autophagy. 2015 Nov, 11(12): 2172-2183.
2.D Ge, L Han, S Huang, N Peng, P Wang, Z Jiang, J Zhao, L Su, S Zhang, Y Zhang, H Kung, B Zhao*, J Miao*. Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells. Autophagy. 2014 Jun;10(6):957-71.
3.L Zhang, J Zhao, L Su, B Huang, L Wang, H Su, Y Zhang, S Zhang, J Miao*. D609 inhibits progression of preexisting atheroma and promotes lesion stability in apolipoprotein e-/- mice: a role of phosphatidylcholine-specific phospholipase in atherosclerosis. Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):411-8.
4. L Wang, Z DongZ Dong, B Huang, B Zhao*, H Wang, J Zhao, H Kung, S Zhang, J Miao*. Distinct Patterns of Autophagy Evoked by Two Benzoxazine Derivatives in Vascular Endothelial Cells. Autophagy, 2010, Nov 15;6(8):1115-24.
5.N Peng, N Meng, S Wang, F Zhao, J Zhao, L Su, S Zhang, Y Zhang, B Zhao*, J Miao*. An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E⁻/⁻ mice. Sci Rep. 2014 Jul 1;4:5519.
6.H Ma, L Su, H Yue, X Yin, J Zhao, S Zhang, H Kung, Z Xu*, J Miao*. HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in vascular endothelial cells. Sci Rep. 2015 Oct 12;5:15121.
7. L Wang, H Li, J Zhang, W Lu, J Zhao, L Su, B Zhao*, Y Zhang, S Zhang, J Miao*. Phosphatidylethanolamine binding protein 1 in vacular endothelial cell autophagy and atherosclerosis. J Physiol. 2013 Oct 15;591(Pt 20):5005-15.
8.H Li, N Liu, S Wang, L Wang, J Zhao, L Su, Y Zhang, S Zhang, Z Xu, B Zhao*, J Miao*. Identification of a small molecule targeting annexin A7. Biochim Biophys Acta (BBA-MOL CELL RES.) 2013 Sep;1833(9):2092-9.
9.SY Liu, D Ge, LN Chen, J Zhao, L Su, S ZhangL, JY Miao*, BX Zhao*. A small molecule induces integrin β4 nuclear translocation and apoptosis selectively in cancer cells with high expression of integrin β4. Oncotarget. 2016 Mar 29;7(13):16282-96.
10.W Lu, SY Huang, L Su, BX Zhao*, JY Miao*. Long Noncoding RNA LOC100129973 Suppresses Apoptosis by Targeting miR-4707-5p and miR-4767 in Vascular Endothelial Cells. Sci Rep. 2016 Feb 18;6:21620.
PATENTS
1. Application of 2, 3 - dihydro-3 - hydroxymethyl -6 - amino - [1,4 ] - benzoxazine in Preparation of Drugs Inducing Embryonic Stem Cells to Differentiate to Vascular Endothelial Cells
Inventors：Junying Miao, Baoxiang Zhao, Shangli Zhang, Jing Zhao, Le Su, Lei Han
Patent No.: US9, 101, 634 B2
Date of Patent：Aug. 11, 2015
AWARDS
1. Natural Science Award of Shandong Province (ZR2010-2-8-2), 2010
2. Natural Science Award of Shandong Province (Z2002-3-11-1), 2002
